Revolution Plus is used in the prevention, control, and treatment of various parasite infections. The active ingredients are sarolander and selamectin, which interfere with the parasite's nervous system. It is an effective heartworm preventive, killing the immature form of the heartworm (Dirofilaria immitis). It kills adult fleas (Ctenocephalides felis) and prevents flea eggs from hatching for one month. It is also used for the treatment and control of ear mites (Otodectes cynotis). Revolution Plus is effective in controlling tick infestations. Revolution Plus also treats and controls roundworm and hookworm infections.